abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

journal_title：Thrombosis and haemostasis

authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

更新日期：2014-03-03 00:00:00

abstract：:Platelet adhesion and aggregation at the sites of vascular injury are key events for thrombosis and haemostasis. It has been well demonstrated that interaction between glycoprotein (GP) Ibα and von Willebrand factor (VWF) initiates platelet adhesion and contributes to platelet aggregation, particularly at high shear. ...

journal_title：Thrombosis and haemostasis

authors： Lei X,Reheman A,Hou Y,Zhou H,Wang Y,Marshall AH,Liang C,Dai X,Li BX,Vanhoorelbeke K,Ni H

更新日期：2014-02-01 00:00:00

abstract：:The introduction of venography into patient care was a major advance because it was the first accurate method for the diagnosis of DVT. Compression ultrasound has since become the preferred test for patients with suspected DVT because, unlike venography, it is simple, non-invasive and widely available. Venography has ...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Ginsberg JS,Chan N,Guyatt G,Eikelboom JW

更新日期：2014-01-01 00:00:00

abstract：:Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

journal_title：Thrombosis and haemostasis

authors： Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

更新日期：2014-01-01 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis and haemostasis

authors： Metzner HJ,Pipe SW,Weimer T,Schulte S

更新日期：2013-11-01 00:00:00

abstract：:Platelets are critically involved in atherosclerosis and acute thrombosis. The platelet phenotype shows a wide variability documented by the inherited difference of platelet reactivity, platelet volume and count and function of platelet surface receptors. Several candidate genes have been put into focus and investigat...

journal_title：Thrombosis and haemostasis

authors： Geisler T,Schaeffeler E,Gawaz M,Schwab M

更新日期：2013-11-01 00:00:00

abstract：:Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (...

journal_title：Thrombosis and haemostasis

authors： Braunersreuther V,Montecucco F,Pelli G,Galan K,Proudfoot AE,Belin A,Vuilleumier N,Burger F,Lenglet S,Caffa I,Soncini D,Nencioni A,Vallée JP,Mach F

更新日期：2013-10-01 00:00:00

abstract：:In patients with atrial fibrillation (AF) undergoing coronary stent implantation, the optimal antithrombotic strategy is unclear. We evaluated whether use of oral anticoagulation (OAC) was associated with any benefit in morbidity or mortality in patients with AF, high risk of thromboembolism (TE) (CHA2DS2-VASC score ≥...

journal_title：Thrombosis and haemostasis

authors： Bernard A,Fauchier L,Pellegrin C,Clementy N,Saint Etienne C,Banerjee A,Naudin D,Angoulvant D

更新日期：2013-09-01 00:00:00

abstract：:Using gain-of-function factor IX (FIX) for replacement therapy for haemophilia B (HB) is an attractive strategy. We previously reported a high-activity FIX, FIX-Triple (FIX-V86A/E277A/R338A) as a good substitute for FIX-WT (wild-type) in protein replacement therapy, gene therapy, and cell therapy. Here we generated a ...

journal_title：Thrombosis and haemostasis

authors： Kao CY,Yang SJ,Tao MH,Jeng YM,Yu IS,Lin SW

更新日期：2013-08-01 00:00:00

abstract：:Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal dose for the individual patient may be useful in some situations. Moreover, there is a need for clinicians to know whether coagulation assays are influenced by apixaban use. The aim of this study was to determine whic...

journal_title：Thrombosis and haemostasis

authors： Douxfils J,Chatelain C,Chatelain B,Dogné JM,Mullier F

更新日期：2013-08-01 00:00:00

abstract：:Haemophilia A and B have been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD in haemophilia.The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 1...

journal_title：Thrombosis and haemostasis

authors： Anagnostis P,Vyzantiadis TA,Charizopoulou M,Adamidou F,Karras S,Goulis DG,Karagiannis A,Garipidou V,Vakalopoulou S

更新日期：2013-08-01 00:00:00

abstract：:Patients with both chronic kidney disease (CKD) and diabetes mellitus (DM) are at increased risk for thrombotic events compared to those with one abnormality alone. Whether this can be attributed to changes in platelet reactivity among those with both CKD and DM is unknown. We prospectively studied 438 clopidogrel-naï...

journal_title：Thrombosis and haemostasis

authors： Baber U,Bander J,Karajgikar R,Yadav K,Hadi A,Theodoropolous K,Gukathasan N,Roy S,Sayeneni S,Scott SA,Kovacic JC,Yu J,Sartori S,Mehran R,Uribarri J,Badimon JJ,Muntner P,Moreno P,Kini AS,Sharma SK

更新日期：2013-07-01 00:00:00

abstract：:Recurrent joint bleeding is the most common manifestation of haemophilia resulting in haemophilic arthropathy (HA). The exact pathophysiology is unknown, but it is suggested that arthropathy is stimulated by liberation of fibrinolytic activators from the synovium during haemarthrosis. The aim of this study was to test...

journal_title：Thrombosis and haemostasis

authors： Nieuwenhuizen L,Roosendaal G,Coeleveld K,Lubberts E,Biesma DH,Lafeber FP,Schutgens RE

更新日期：2013-07-01 00:00:00

abstract：:Factor V Leiden is a procoagulant mutation associated with venous and arterial thrombosis and pregnancy complications. Its high prevalence of 5% in Caucasians suggests that there are evolutionary benefits as well. Carriers are indeed reported to have various advantageous phenotypes related to haemostasis, inflammation...

journal_title：Thrombosis and haemostasis

authors： van Mens TE,Levi M,Middeldorp S

更新日期：2013-07-01 00:00:00

abstract：:The clinical severity in some patients with haemophilia A appears to be unrelated to the levels of factor (F)VIII activity (FVIII:C), but mechanisms are poorly understood. We have investigated a patient with a FVIII gene mutation at Arg1781 to His (R1781H) presenting with a mild phenotype despite FVIII:C of 0.9 IU/dl....

journal_title：Thrombosis and haemostasis

authors： Yada K,Nogami K,Wakabayashi H,Fay PJ,Shima M

更新日期：2013-06-01 00:00:00

abstract：:Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells, but the underlying mechanisms are not fully understood. In this study, we tested the hypothesis that hyperglycaemia causes dysfunction of the endothelial membrane protein annexin A2, thereby leading to an overall reduction of fibrinolyti...

journal_title：Thrombosis and haemostasis

authors： Dai H,Yu Z,Fan X,Liu N,Yan M,Chen Z,Lo EH,Hajjar KA,Wang X

更新日期：2013-06-01 00:00:00

abstract：:Unfractionated heparin is the most commonly used anticoagulant in ST-elevation myocardial infarction (STEMI) and its effect can be monitored with activated partial thromboplastin time (aPTT). However, the optimal aPTT range during heparin therapy after primary percutaneous coronary intervention (PCI) is yet to be defi...

journal_title：Thrombosis and haemostasis

authors： Kikkert WJ,van Nes SH,Lieve KV,Dangas GD,van Straalen J,Vis M,Baan J Jr,Koch KT,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2013-05-01 00:00:00

abstract：:In the last decade, several studies revealed inter-patient response variability to antiplatelet agents: patients who display negligible or no responses to these drugs are considered poor responders, or "resistant" to treatment. In order to identify poor responders to an antiplatelet drug, laboratory tests of platelet ...

journal_title：Thrombosis and haemostasis

authors： Cattaneo M

更新日期：2013-05-01 00:00:00

abstract：:Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective a...

journal_title：Thrombosis and haemostasis

authors： Ding Q,Yang L,Hassanian SM,Rezaie AR

更新日期：2013-04-01 00:00:00

abstract：:Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP pa...

journal_title：Thrombosis and haemostasis

authors： Haselboeck J,Kaider A,Pabinger I,Panzer S

更新日期：2013-04-01 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

journal_title：Thrombosis and haemostasis

authors： Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

更新日期：2013-03-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

journal_title：Thrombosis and haemostasis

authors： Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

更新日期：2013-03-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer developme...

journal_title：Thrombosis and haemostasis

authors： Asare Y,Schmitt M,Bernhagen J

更新日期：2013-03-01 00:00:00

abstract：:Fibrin polymerisation is mediated by interactions between knobs 'A' and 'B' exposed by thrombin cleavage, and holes 'a' and 'b'. We demonstrated markedly delayed thrombin-catalysed fibrin polymerisation, through B:b interactions alone, of recombinant γD364H -fibrinogen with impaired hole 'a'. To determine whether reco...

journal_title：Thrombosis and haemostasis

authors： Soya K,Terasawa F,Okumura N

更新日期：2013-02-01 00:00:00

abstract：:Limited data are available on the role of monocytes in cardiac repair. In the present study, we evaluated the dynamic alterations of monocytes with reparative and angiogenic potential in patients with myocardial infarction(MI). Reparative CXCR4+ monocytes, and CD34+ and KDR+ monocytes with angiogenic potential derived...

journal_title：Thrombosis and haemostasis

authors： Shantsila E,Tapp LD,Wrigley BJ,Montoro-García S,Lip GY

更新日期：2013-02-01 00:00:00

abstract：:In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

journal_title：Thrombosis and haemostasis

authors： Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

更新日期：2013-01-01 00:00:00

abstract：:Global coagulation assays display variable effects at different concentrations of rivaroxaban. The aim of this study is to quantify the ex vivo effects of low-dose rivaroxaban on thrombophilia screening assays and coagulation factor activities based on the administration time, and to show how to mask possible inter...

journal_title：Thrombosis and haemostasis

authors： Mani H,Hesse C,Stratmann G,Lindhoff-Last E

更新日期：2013-01-01 00:00:00

abstract：:Duplex ultrasound is the first-line diagnostic test for detecting lower limb deep-vein thrombosis (DVT) but it is time consuming, requires patient transport, and cannot be interpreted by most physicians. The accuracy of emergency physician-performed ultrasound (EPPU) for the diagnosis of DVT, when performed at the bed...

journal_title：Thrombosis and haemostasis

authors： Pomero F,Dentali F,Borretta V,Bonzini M,Melchio R,Douketis JD,Fenoglio LM

更新日期：2013-01-01 00:00:00

abstract：:The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A total of ...

journal_title：Thrombosis and haemostasis

authors： Berger JS,Becker RC,Kuhn C,Helms MJ,Ortel TL,Williams R

更新日期：2013-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterised by increased pressure in the pulmonary arteries leading to right-sided ventricular failure, and death. Identification of factors that affect patient survival is important to improve patient management and outcomes. The first registry to evaluate survival and devel...

journal_title：Thrombosis and haemostasis

authors： Benza RL,Gomberg-Maitland M,Frost AE,Frantz RP,Humbert M,McGoon MD

更新日期：2012-12-01 00:00:00

abstract：:Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS) to catalyse the activation of factor X (FX) to factor Xa (FXa) in the intrinsic pathway. Fluorescence resonance energy transfer (FRET) studies have indicated th...

journal_title：Thrombosis and haemostasis

authors： Qureshi SH,Yang L,Rezaie AR

更新日期：2012-12-01 00:00:00

abstract：:Limited data exist on thrombophilia and the risk of venous thrombosis (VT) during pregnancy and postpartum. The objectives of the present study were to investigate the role of haemostatic risk factors for pregnancy-related VT and their phenotypic expression in deep-vein thrombosis (DVT) and pulmonary embolism (PE). To...

journal_title：Thrombosis and haemostasis

authors： Bergrem A,Dahm AE,Jacobsen AF,Sandvik L,Sandset PM

更新日期：2012-12-01 00:00:00

abstract：:Plaque rupture followed by thrombosis is the underlying cause of the majority of acute coronary syndromes. Circulating microparticles (cMPs), membrane blebs released into blood by activated cells, have been associated to vascular diseases. Specifically, high levels of platelet-derived microparticles (pMPs) have been f...

journal_title：Thrombosis and haemostasis

authors： Suades R,Padró T,Vilahur G,Badimon L

更新日期：2012-12-01 00:00:00

abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

journal_title：Thrombosis and haemostasis

authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

更新日期：2012-11-01 00:00:00

abstract：:The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for ...

journal_title：Thrombosis and haemostasis

authors： McNeill E,Channon KM

更新日期：2012-11-01 00:00:00

abstract：:Bleeding and thrombotic disorders are major complications affecting patients with chronic kidney disease (CKD). Exposure of circulating platelets to uraemic toxins and contact with artificial surfaces during dialysis induce platelet abnormalities and alter the platelet proteome. We hypothesised that these changes may ...

journal_title：Thrombosis and haemostasis

authors： Plé H,Maltais M,Corduan A,Rousseau G,Madore F,Provost P

更新日期：2012-10-01 00:00:00